After several years of work and discussion, the taxonomy of the genus Lactobacillus is modified. This change will have many economic, scientific and regulatory consequences.

Why is the Lactobacillus taxonomy changing?

What is taxonomy? This is the science that classifies, groups and names living organisms.

Lactobacilli were first described in 1901 with Lactobacillus delbrueckii, an essential species for the yogurt production. Over time, thanks to new methods of genetic sequencing, more than 260 different species of Lactobacilli have been identified.

The accepted normal diversity being exceeded, it is no longer possible to reasonably and coherently group these species because of the great heterogeneity that this generates. Reclassification is necessary. Lactobacilli are now limited to only 35 species according to the International Journal of Systematic and Evolutionary Microbiology (IJSEM) publication dated April 15, 2002. The rest were dispersed and grouped into 23 new smaller genus. This reclassification work was titanic!

All these new genus:

  • Meet the rules of homogeneity between organisms
  • Provide more specificity, ensuring stronger and clearer scientific evidence
  • Are stable in the long term
  • Allow to integrate new species
  • Begin with the letter “L”
  • Keep a resemblance to “Lactobacillus”

For example, species :

  • delbrueckii, acidophilus, gasseri, crispatus… always belong to the genus Lactobacillus
  • rhamnosus, casei and paracasei now belong to the genus Lacticaseibacillus
  • plantarum and pentosus of the genus Lactiplantibacillus
  • reuteri and fermentum in the genus Limosilactobacillus

The University of Alberta created a very useful tool for finding new genus names from old ones (

What are the different challenges of this taxonomy modification?

Considerable work is to be considered for companies working in probiotics and authorities as well. Indeed, this reclassification leads to an update of the various documents by the manufacturers (labeling, packaging, websites, technical / quality / commercial documents…).

EFSA, Santé Canada and the FDA will now use the new names in their publications and communications, including for positive lists.

Scientific research and patent applications will have to take these new names into account. During bibliographic searches, it will be important to look for publications with new but also old names of genus.

Internal and external communication will also be greatly impacted. It will be a key step in order to provide the information necessary for understanding whether it is with laboratories, healthcare professionals, consumers or regulatory authorities. For example, by linking clinical trials using the old genus name with a product containing the probiotic with the new name.


This large-scale work is an important change in the history of probiotic bacteria. And that is just the beginning. Applicable on a global scale, all the parties concerned will have to demonstrate adaptability and pedagogy in order to understand, and make understood this new taxonomy. Although it is not enforceable, it is strongly encouraged.



PARKS DH, CHUVOCHINA M, WAITE DW, RINKE C, SKARSHEWSKI A, CHAUMEIL PA, HUGENHOLTZ P. A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life. Nat Biotechnol. 2018, 36(10):996-1004 

SALVETTI E, HARRIS HMB, FELIS GE, O’TOOLE PW. Comparative genomics of the genus Lactobacillus reveals robust phylogroups that provide the basis for reclassification. Appl Environ Microbiol. 2018, 84(17)

ZHENG J, RUAN L, SUN M, GÄNZLE M. A genomic view of Lactobacilli and Pediococci demonstrates that phylogeny matches ecology and physiology. Appl Environ Microbiol. 2015, 81(20):7233-43